2 edition of Theoretical and experimental studies on mutational spectra and hot-spots. found in the catalog.
Theoretical and experimental studies on mutational spectra and hot-spots.
Sana Nasrat Al-Kaysi
Thesis (Ph.D.) - University of East Anglia, School of Biological Sciences, 1976.
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The essential enzyme CYP is a target for drug development against antibiotic resistant strains of Mycobacterium tuberculosis. A triazolyl phenol fragment 1 was identified to bind to CYP using a cascade of biophysical assays. Synthetic merging and optimization of 1 produced a fold improvement in binding affinity, yielding lead compound 2 (KD = 15 μM).Cited by: Bioinformatics A Practical Approach Cindb 1 7/18/07 AM CHAPMAN & HALL/CRC Mathematical and Computatio 1 downloads Views 31MB Size
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Many studies have identified specific DNA sequence patterns associated with elevated mutation frequency ().For example, repetitive sequences such as homonucleotide runs, direct and inverted repeats and microsatellite repeats are involved in specific types of high frequency mutational events (reviewed in).For these mutation hotspots, the exact DNA sequence is not critical but only the fact Cited by: Mutation Research, 36 () lsevier Scientific Publishing Company, Amsterdam - Printed in The Netherlands INTRAGENIC MUTATIONAL SPECTRA AND HOT SPOTS C.H.
CLARKE and A.W.B. JOHNSTON School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ and Institute of Animal Genetics, University of Edinburgh (U.K.) (Received December 11th, ) Cited by: Rogozin, I.B.
& Pavlov, Y.I. Theoretical analysis of mutation hotspots and their DNA sequence specificity. Mutat. Res.DNA mismatch repair is a highly conserved DNA repair pathway. In humans, germline mutations in hMSH2 or hMLH1, key components of mismatch repair, have been associated with Lynch syndrome, a leading cause of inherited cancer t estimates of the mutation rate and the mutational spectra in mismatch repair defective cells are primarily limited to a small number of individual Cited by: The purpose of this review is to summarize the evidence that can be used to reconstruct the etiology of human cancers from mutations found in tumors.
Mutational spectra of the tumor suppressor gene p53 (TP53) are tumor specific. In several cases, these mutational spectra can be linked to exogenous carcinogens, most notably for sunlight-associated skin cancers, tobacco-associated Cited by: The variation among independent experiments is consistent with the numerical expectation that all 16 mutations fulfill reasonable statistical criteria for mutational hot spots.
The agreement with data from various systems using clone-by-clone analysis shows that the protocol reported herein can be a useful tool to study hot-spot point Cited by: The REGRT program developed has been tested on simulated and real mutational spectra.
For the G:C-->T:A mutational spectra induced by Sn1 alkylating agents (nine spectra), the prediction accuracy. Experimental investigations have shown that the. hot spots. for oxidative damage in the DNA molecule are the guanine bases, either single or stacked .
The guanine base has the lowest ionization potential among all bases in the DNA molecule and is the preferred spot for the oxidative damage. However, the. Abstract. The events leading to cancer are complex and interactive. Alteration of cancer genes, such as the tumor suppressor gene p53, plays a central role in this is of the frequency, type and site of mutations in important cancer-related genes may provide clues to the identification of etiological factors and sources of by: Study 56 Ch 12 Gene Mutation flashcards from Jacqueline D.
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acme products is concerned about. DNA methylation, occurring at the 5 position of cytosine, is a natural process associated with mutational hotspots in skin tumors.
By combining experimental techniques (optical spectroscopy, HPLC coupled to mass spectrometry) with theoretical methods (molecular dynamics, DFT/TD-DFT calculations in solution), we study trinucleotides with key sequences (TCG/T5mCG) in the UV-induced DNA by: Free-energy calculations in the framework of classical molecular dynamics simulations are nowadays used in a wide range of research areas including solvation thermodynamics, molecular recognition, and protein folding.
The basic components of a free-energy calculation, that is, a suitable model Hamiltonian, a sampling protocol, and an estimator for the free energy, are independent of the Cited by: This work includes a nearly complete set of organic molecules for which reliable gas-phase experimental spectra have been assigned and is much more extensive than widely-quoted compila- tions of this type The quality of the fit with experimental infrared spectra is now suffi- ciently good that these methods promise to be of practical use in.
Retroviruses are RNA viruses that replicate through a DNA intermediate, in a process catalyzed by the viral reverse transcriptase (RT). Although cellular polymerases and host factors contribute to retroviral mutagenesis, the RT errors play a major role in retroviral mutation.
RT mutations that affect the accuracy of the viral polymerase have been identified by in vitro analysis of the fidelity Cited by: His experimental system was the r II region of bacteriophage T4.
Comparing Jan's data with S eymour B enzer 's r II spectrum for spontaneous mutations (B enzer ), it became immediately clear that the spectra, the positions of “hot spots” and the mutational specificities for UV-induced and spontaneous mutations are by: 4.
As a tumor suppressor protein, p53 plays a crucial role in the cell cycle and in cancer prevention. Almost 50 percent of all human malignant tumors are closely related to a deletion or mutation in p The activity of p53 is inhibited by over-active celluar antagonists, especially by the over-expression of the negative regulators MDM2 and MDMX.
Protein-protein interactions, or post Cited by: This book, together with vols. 1 and 2, is the first to provide an encyclopedic view of fundamental physical limnology up to The ideal resource for graduate courses in physical oceanography and limnology Provides in-depth information on theoretical, experimental (laboratory and field) techniques for water and sediment.
RESEARCH PROGRAM The ORD research program is administered through 4 Offices and implemented by 15 Laboratories: FY ($1,OOP's) FY ($'s) Office of Health and Ecologi 73, Effects Office of Energy, Minerals, 92, Industry Office of Air, Land and Water 61, Office of Monitoring and Techni 24, Support Program Areas 1.
Experimental evolution is a method in which populations of organisms, often microbes, are founded by one or more ancestors of known genotype and then propagated under controlled conditions to study the evolutionary process.
These evolving populations are influenced by all population genetic forces, including selection, mutation, drift, and recombination, and the relative contributions of these Cited by: Suggested Citation:"4 Areas That Could Benefit from Augmentation and Integration."National Research Council.
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Library of Congress Cataloging-in-Publication Data Molecular carcinogenesis and the molecular biology of human cancer / edited by David Warshawsky, Joseph R. Landolph.